Wade Wilson is one weird character. Marvel’s Deadpool has broken the fourth wall many times, proving his awareness of his fictional existence.
For example, when a character asks him “Why did you do that?”, he replies:
Because you were gonna do it and this is my book.
Other famous 4th wall-breakers include The Joker who, in Batman’s Animated Series, would frequently talk to the camera, as if he was directly talking to the viewers at home.